Fenbendazole Capsules

Fenbendazole is a drug widely used to eradicate pinworms, roundworms, hookworms and lungworms in dogs. It is also known to prevent the growth of a number of cancers.

In experiments examining its radiation effects, it was found that fenbendazole did not alter the growth of unirradiated or irradiated tumors. It is therefore likely that this compound would not be useful as a radiosensitizer.

Dosage

Fenbendazole is an antiparasitic drug in the benzimidazole family. It is effective against many internal parasites including roundworms, hookworms, whipworms, lungworms and protozoal parasites such as Giardia. It is not effective against tapeworms (Taenia species) or heartworms.

It kills parasites by binding to tubulin and disrupting the microtubule equilibrium of the affected parasites. It also interferes with metabolism in affected parasites. Intensive doses of fenbendazole have been shown to be toxic to cancer cells in vitro and to suppress tumor growth when combined with radiation or chemotherapy.

Drooling and vomiting are sometimes seen as a side effect of fenbendazole, but these effects are not typically severe and can be minimized by following the Joe Tippens protocol for treatment of cancer with this dewormer. The protocol recommends weekly cycles of 3 days on and 4 days off to allow the liver a break from the detoxification process and to keep the immune system in optimal health.

Administration

When fenbendazole is given orally to dogs, cats, and horses, it kills parasites in the intestines. The benzimidazole kills parasites by binding to the DNA of those organisms and inhibiting their growth. It does not affect normal cells, and fenbendazole is well-tolerated by most pets.

This medication is available in capsule and oral tablet form. It can be used alone or in conjunction with other medications. It may be prescribed as a compounded drug, which means it is made by a licensed pharmacist on an individual basis for your pet.

Compounding is a way to customize your pet’s medication in situations when it cannot be adequately managed with FDA-approved medications. Veterinarians may recommend compounding when your pet has difficulty taking pills in capsule form, the dosage strength is not commercially available, or your pet has an allergic reaction to a specific ingredient found in an FDA-approved medication. This approach allows for more customization of your pet’s treatment plan and helps to reduce side effects.

Side Effects

Fenbendazole is a broad spectrum anthelmintic that has no known toxic effects when used as directed. Side effects are rare, but may include diarrhea as the body expels parasites that have been killed by fenbendazole. If this occurs, contact your veterinarian for further instructions.

In cell cultures, fenbendazole significantly reduces BoHV-1 viral production by inhibiting microtubule formation. Virus titers were reduced by up to 1.5-log when the drug was present at concentrations of 20 and 80 nM (Fig. 1B, lower panel).

In vivo studies using fenbendazole have demonstrated that it has no significant effect on tumor growth either in unirradiated or irradiated mice. However, it is important to discuss any supplements that your pet may be taking with a veterinarian prior to treatment. Preparations of fenbendazole developed for larger animals should not be used in small dogs or cats as they contain ingredients that are toxic to these species. Veterinary compounders like SVPMEDS can prepare medication specifically for your pet’s size that is safe and effective.

Storage

The medication should be stored in a sealed container at room temperature and protected from sunlight. Follow the storage recommendations on the label or those provided by your veterinarian.

Fenbendazole is not absorbed well by poultry, and it is rapidly eliminated from the body, predominately in feces. Therefore, its effectiveness against encysted third-stage small strongyles (Giardia) relies on its ability to penetrate the encysted eggs, rather than its absorption or metabolism by the host chicken.

This compound prescription contains an oil and a suspension of the medication, which must be shaken well before each dose. Each bottle has a clear bottle adapter that seals the top of the prescription; please do not remove this or you will lose part of your 1 to 1 dilution, which is critical for proper administration.

At regular doses, fenbendazole does not usually cause side effects. However, if the dose is higher than recommended, substances released by dying parasites can cause an allergic reaction. This can include facial swelling, hives, trouble breathing and collapse. If your pet shows any signs of an allergic reaction, seek veterinary care immediately. fenbendazole capsules